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Interestingly, neurons are thought to metabolize glucose primarily via the pentose phosphate pathway (PPP) to provide reducing equivalents required to maintain antioxidant defenses via the production of nicotinamide adenine dinucleotide phosphate (NADPH) (Figure 1.2 and 2.5) [39]

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9 Despite its severity, DN has received comparatively less attention in clinical research and therapeutic development than other diabetic complications, such as nephropathy and retinopathy, necessitating further research

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